Gerdt Laboratory

Chemical inhibition of cell surface modification sensitizes bacteria to phage infection

Addo, M.A., Zang, Z., Gerdt, J.P. RSC Chemical biology. 2024. DOI: 10.1039/d4cb00070f

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Lipids from a snail host regulate the multicellular behavior of a predator of parasitic schistosomes

Kidner, R. Q., Goldstone, E. B., Laidemitt, M. R., Sanchez, M. C., Gerdt, C., Brokaw, L. P., Ros-Rocher, N., Morris, J., Davidson, W. S., Gerdt, J. P. iScience. 2024. DOI: 10.1016/j.isci.2024.110724  

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Exogenous lipid vesicles induce endocytosis-mediated cellular aggregation in a close unicellular relative of animals

Kidner, R. Q., Goldstone, E. B., Rodefeld, H. J., Brokaw, L. P., Gonzalez, A. M., Ros-Rocher, N., Gerdt, J. P. preprint

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Host lipids regulate multicellular behavior of a predator of a human pathogen

Kidner, R. Q., Goldstone, E. B., Laidemitt, M. R., Sanchez, M. C., Gerdt, C., Brokaw, L. P., Ros-Rocher, N., Morris, J., Davidson, W. S.. Gerdt, J. P. preprint.

Bacterium secretes chemical inhibitor that sensitizes competitor to bacteriophage infection

Zang, Z., Zhang, C. Park, K. J., Schwartz, D. A., Podicheti, R., Lennon, J. T., Gerdt, J. P. preprint. 

Interbacterial biofilm competition through a suite of secreted metabolites

Rayi, S., Cai, Y., Greenwich, J., Fuqua, C., Gerdt, J. P. ACS Chemical Biology. 2024. DOI: 10.1021/acschembio.3c00655

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Ravidomycin analogs from Streptomyces sp. exhibit altered antimicrobial and cytotoxic selectivity

Park, KJ.; Maier, S.; Zhang, C.; Dixon, S.; Rusch, D.; Pupo, M.; Angus, S.; Gerdt, J. P. Journal of Natural Products. 2023. DOI: 10.1021/acs.jnatprod.3c00381

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Chemical factors induce aggregative multicellularity in a close unicellular relative of animals

Ros-Rocher, N.; Kidner, R.; Gerdt, C.; Davidson, W.; Ruiz-Trillo, I.; Gerdt, J. P. PNAS. 2023. 120 (18) e2216668120

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A Metabolite Produced by Gut Microbes Represses Phage Infections in Vibrio cholerae

Zang, Z.; Park, K. J.; Gerdt, J. P. ACS Chem. Biol. 2022. 17, 9, 2396–2403.

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Chemical Ecology of Choanoflagellates

Gerdt, J. P. “Chemical Ecology of Choanoflagellates,” In Comprehensive Natural Products III: Chemistry and Biology, Eds. Begley, T. P., Liu, H-W. 2019

Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum

Brancucci, N. M. B.*; Gerdt, J. P.*; Wang, C.; Niz, M. D.; Philip, N.; Adapa, S. R.; Zhang, M.; Hitz, E.; Niederwieser, I.; Boltryk, S. D.; Laffitte, M.-C.; Clark, M. A.; Grüring, C.; Ravel, D.; Soares, A. B.; Demas, A.; Bopp, S.; Rubio-Ruiz, B.; Conejo-Garcia, A.; Wirth, D. F.; Gendaszewska-Darmach, E.; Duraisingh, M. T.; Adams, J. H.; Voss, T. S.; Waters, A. P.; Jiang, R. H. Y.; Clardy, J.; Marti, M. “Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum” Cell 2017, 171:1532–1544.

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Mating in the closest living relatives of animals is induced by a bacterial chondroitinase

Woznica, A.*; Gerdt, J. P.*; Hulett, R. E.; Clardy, J.; King, N. “Mating in the closest living relatives of animals is induced by a bacterial chondroitinase” Cell 2017, 170:1175–1183.

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Chemical interrogation of LuxR-type quorum sensing receptors reveals new insights into receptor selectivity and the potential for interspecies bacterial signaling

Gerdt, J. P.*; Wittenwyler, D. M.*; Combs, J. B.; Boursier, M. E.; Brummond, J. W.; Xu, H.; Blackwell, H. E. “Chemical interrogation of LuxR-type quorum sensing receptors reveals new insights into receptor selectivity and the potential for interspecies bacterial signaling” ACS Chem. Biol. 2017, 12:2457–2464.

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Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR

Gerdt, J. P.*; McInnis, C. E.*; Schell, T. L.; Blackwell, H. E. “Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR” Org. Biomol. Chem. 2015, 13:1453–1462.

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Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by non-lactone ligands

Gerdt, J. P.*; McInnis, C. E.*; Schell, T. L.; Rossi, F. M.; Blackwell, H. E. “Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by non-lactone ligands” Chem. Biol. 2014, 21:1361–1369.

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Competition studies reveal two major barriers that will preclude the spread of resistance to quorum-sensing inhibitors in bacteria

Gerdt, J. P.; Blackwell, H. E. “Competition studies reveal two major barriers that will preclude the spread of resistance to quorum-sensing inhibitors in bacteria” ACS Chem. Biol. 2014, 9:2291–2299.

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Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa

Moore, J. D.; Gerdt, J. P.; Eibergen, N. R.; Blackwell, H. E. “Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa” ChemBioChem 2014, 15:435–442.

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Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2',3'-cyclic phosphate RNA substrates

Kost, D. M.*; Gerdt, J. P.*; Pradeepkumar, P. I.; Silverman, S. K. “Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn²⁺-dependent deoxyribozymes that use 2',3'-cyclic phosphate RNA substrates” Org. Biomol. Chem. 2008, 6:4391–4398.

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Selective stabilization of natively folded RNA structure by DNA constraints

Gerdt, J. P.; Miduturu, C. V.; Silverman, S. K. “Selective stabilization of natively folded RNA structure by DNA constraints” J. Am. Chem. Soc. 2008, 130:14920–14921.

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