Publications
Ravidomycin analogs from Streptomyces sp. exhibit altered antimicrobial and cytotoxic selectivity
Park, KJ.; Maier, S.; Zhang, C.; Dixon, S.; Rusch, D.; Pupo, M.; Angus, S.; Gerdt, J. P. Journal of Natural Products. 2023. DOI: 10.1021/acs.jnatprod.3c00381
Chemical factors induce aggregative multicellularity in a close unicellular relative of animals
, , R.; , C.; , W.; , I.; 120 (18) e2216668120
A Metabolite Produced by Gut Microbes Represses Phage Infections in Vibrio cholerae
Zang, Z.; Park, K. J.; Gerdt, J. P. ACS Chem. Biol. 2022. 17, 9, 2396–2403.
Chemical Ecology of Choanoflagellates
Gerdt, J. P. “Chemical Ecology of Choanoflagellates,” In Comprehensive Natural Products III: Chemistry and Biology, Eds. Begley, T. P., Liu, H-W. 2019
Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum
Brancucci, N. M. B.*; Gerdt, J. P.*; Wang, C.; Niz, M. D.; Philip, N.; Adapa, S. R.; Zhang, M.; Hitz, E.; Niederwieser, I.; Boltryk, S. D.; Laffitte, M.-C.; Clark, M. A.; Grüring, C.; Ravel, D.; Soares, A. B.; Demas, A.; Bopp, S.; Rubio-Ruiz, B.; Conejo-Garcia, A.; Wirth, D. F.; Gendaszewska-Darmach, E.; Duraisingh, M. T.; Adams, J. H.; Voss, T. S.; Waters, A. P.; Jiang, R. H. Y.; Clardy, J.; Marti, M. “Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum” Cell 2017, 171:1532–1544.
Mating in the closest living relatives of animals is induced by a bacterial chondroitinase
Woznica, A.*; Gerdt, J. P.*; Hulett, R. E.; Clardy, J.; King, N. “Mating in the closest living relatives of animals is induced by a bacterial chondroitinase” Cell 2017, 170:1175–1183.
Chemical interrogation of LuxR-type quorum sensing receptors reveals new insights into receptor selectivity and the potential for interspecies bacterial signaling
Gerdt, J. P.*; Wittenwyler, D. M.*; Combs, J. B.; Boursier, M. E.; Brummond, J. W.; Xu, H.; Blackwell, H. E. “Chemical interrogation of LuxR-type quorum sensing receptors reveals new insights into receptor selectivity and the potential for interspecies bacterial signaling” ACS Chem. Biol. 2017, 12:2457–2464.
Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR
Gerdt, J. P.*; McInnis, C. E.*; Schell, T. L.; Blackwell, H. E. “Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR” Org. Biomol. Chem. 2015, 13:1453–1462.
Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by non-lactone ligands
Gerdt, J. P.*; McInnis, C. E.*; Schell, T. L.; Rossi, F. M.; Blackwell, H. E. “Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by non-lactone ligands” Chem. Biol. 2014, 21:1361–1369.
Competition studies reveal two major barriers that will preclude the spread of resistance to quorum-sensing inhibitors in bacteria
Gerdt, J. P.; Blackwell, H. E. “Competition studies reveal two major barriers that will preclude the spread of resistance to quorum-sensing inhibitors in bacteria” ACS Chem. Biol. 2014, 9:2291–2299.
Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa
Moore, J. D.; Gerdt, J. P.; Eibergen, N. R.; Blackwell, H. E. “Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa” ChemBioChem 2014, 15:435–442.
Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2',3'-cyclic phosphate RNA substrates
Kost, D. M.*; Gerdt, J. P.*; Pradeepkumar, P. I.; Silverman, S. K. “Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2',3'-cyclic phosphate RNA substrates” Org. Biomol. Chem. 2008, 6:4391–4398.
Selective stabilization of natively folded RNA structure by DNA constraints
Gerdt, J. P.; Miduturu, C. V.; Silverman, S. K. “Selective stabilization of natively folded RNA structure by DNA constraints” J. Am. Chem. Soc. 2008, 130:14920–14921.
A good weekend at the 12th Annual Watanbe Symposium in Chemical Biology! Graduate students Max, Joey and @EmMcRae_Chem all presented their work. Go Giedroc Group!
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great to be at my first @NOBCChE meeting (on my first trip to New Orleans!) representing @IUBChemistry. bummed that family commitments are limiting my stay to a little over 24h… enjoyed the posters tonight—stop by booth 415 tomorrow!
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