Chemical inhibition of cell surface modification sensitizes bacteria to phage infection
September 23, 2024
Addo, M.A., Zang, Z., Gerdt, J.P. RSC Chemical biology. 2024. DOI: 10.1039/d4cb00070f
Archives
Lipids from a snail host regulate the multicellular behavior of a predator of parasitic schistosomes
September 6, 2024
Kidner, R. Q., Goldstone, E. B., Laidemitt, M. R., Sanchez, M. C., Gerdt, C., Brokaw, L. P., Ros-Rocher, N., Morris, J., Davidson, W. S., Gerdt, J. P. iScience. 2024. DOI: 10.1016/j.isci.2024.110724
Exogenous lipid vesicles induce endocytosis-mediated cellular aggregation in a close unicellular relative of animals
August 2, 2024
Kidner, R. Q., Goldstone, E. B., Rodefeld, H. J., Brokaw, L. P., Gonzalez, A. M., Ros-Rocher, N., Gerdt, J. P. preprint
Host lipids regulate multicellular behavior of a predator of a human pathogen
February 1, 2024
Kidner, R. Q., Goldstone, E. B., Laidemitt, M. R., Sanchez, M. C., Gerdt, C., Brokaw, L. P., Ros-Rocher, N., Morris, J., Davidson, W. S.. Gerdt, J. P. preprint.
Bacterium secretes chemical inhibitor that sensitizes competitor to bacteriophage infection
Zang, Z., Zhang, C. Park, K. J., Schwartz, D. A., Podicheti, R., Lennon, J. T., Gerdt, J. P. preprint.
Interbacterial biofilm competition through a suite of secreted metabolites
January 10, 2024
Rayi, S., Cai, Y., Greenwich, J., Fuqua, C., Gerdt, J. P. ACS Chemical Biology. 2024. DOI: 10.1021/acschembio.3c00655
Ravidomycin analogs from Streptomyces sp. exhibit altered antimicrobial and cytotoxic selectivity
August 2, 2023
Park, KJ.; Maier, S.; Zhang, C.; Dixon, S.; Rusch, D.; Pupo, M.; Angus, S.; Gerdt, J. P. Journal of Natural Products. 2023. DOI: 10.1021/acs.jnatprod.3c00381
Chemical factors induce aggregative multicellularity in a close unicellular relative of animals
April 24, 2023
Ros-Rocher, N.; Kidner, R.; Gerdt, C.; Davidson, W.; Ruiz-Trillo, I.; Gerdt, J. P. PNAS. 2023. 120 (18) e2216668120
A Metabolite Produced by Gut Microbes Represses Phage Infections in Vibrio cholerae
August 29, 2022
Zang, Z.; Park, K. J.; Gerdt, J. P. ACS Chem. Biol. 2022. 17, 9, 2396–2403.
Chemical Ecology of Choanoflagellates
September 19, 2019
Gerdt, J. P. “Chemical Ecology of Choanoflagellates,” In Comprehensive Natural Products III: Chemistry and Biology, Eds. Begley, T. P., Liu, H-W. 2019
Lysophosphatidylcholine regulates sexual stage differentiation in the human malaria parasite Plasmodium falciparum
September 19, 2017
Brancucci, N. M. B.*; Gerdt, J. P.*; Wang, C.; Niz, M. D.; Philip, N.; Adapa, S. R.; Zhang, M.; Hitz, E.; Niederwieser, I.; Boltryk, S. D.; Laffitte, M.-C.; Clark, M. A.; Grüring, C.; Ravel, D.; Soares, A. B.; Demas, A.; Bopp, S.; Rubio-Ruiz, B.; Conejo-Garcia, A.; Wirth, D. F.; Gendaszewska-Darmach, E.; Duraisingh, M. T.; Adams, […]
Mating in the closest living relatives of animals is induced by a bacterial chondroitinase
Woznica, A.*; Gerdt, J. P.*; Hulett, R. E.; Clardy, J.; King, N. “Mating in the closest living relatives of animals is induced by a bacterial chondroitinase” Cell 2017, 170:1175–1183.
Chemical interrogation of LuxR-type quorum sensing receptors reveals new insights into receptor selectivity and the potential for interspecies bacterial signaling
Gerdt, J. P.*; Wittenwyler, D. M.*; Combs, J. B.; Boursier, M. E.; Brummond, J. W.; Xu, H.; Blackwell, H. E. “Chemical interrogation of LuxR-type quorum sensing receptors reveals new insights into receptor selectivity and the potential for interspecies bacterial signaling” ACS Chem. Biol. 2017, 12:2457–2464.
Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR
September 19, 2015
Gerdt, J. P.*; McInnis, C. E.*; Schell, T. L.; Blackwell, H. E. “Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR” Org. Biomol. Chem. 2015, 13:1453–1462.
Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by non-lactone ligands
September 19, 2014
Gerdt, J. P.*; McInnis, C. E.*; Schell, T. L.; Rossi, F. M.; Blackwell, H. E. “Mutational analysis of the quorum-sensing receptor LasR reveals interactions that govern activation and inhibition by non-lactone ligands” Chem. Biol. 2014, 21:1361–1369.
Competition studies reveal two major barriers that will preclude the spread of resistance to quorum-sensing inhibitors in bacteria
Gerdt, J. P.; Blackwell, H. E. “Competition studies reveal two major barriers that will preclude the spread of resistance to quorum-sensing inhibitors in bacteria” ACS Chem. Biol. 2014, 9:2291–2299.
Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa
Moore, J. D.; Gerdt, J. P.; Eibergen, N. R.; Blackwell, H. E. “Active efflux influences the potency of quorum sensing inhibitors in Pseudomonas aeruginosa” ChemBioChem 2014, 15:435–442.
Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2′,3′-cyclic phosphate RNA substrates
September 19, 2008
Kost, D. M.*; Gerdt, J. P.*; Pradeepkumar, P. I.; Silverman, S. K. “Controlling the direction of site-selectivity and regioselectivity in RNA ligation by Zn2+-dependent deoxyribozymes that use 2′,3′-cyclic phosphate RNA substrates” Org. Biomol. Chem. 2008, 6:4391–4398.
Selective stabilization of natively folded RNA structure by DNA constraints
Gerdt, J. P.; Miduturu, C. V.; Silverman, S. K. “Selective stabilization of natively folded RNA structure by DNA constraints” J. Am. Chem. Soc. 2008, 130:14920–14921.
A good weekend at the 12th Annual Watanbe Symposium in Chemical Biology! Graduate students Max, Joey and @EmMcRae_Chem all presented their work. Go Giedroc Group!
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great to be at my first @NOBCChE meeting (on my first trip to New Orleans!) representing @IUBChemistry. bummed that family commitments are limiting my stay to a little over 24h… enjoyed the posters tonight—stop by booth 415 tomorrow!
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